REVIEW ARTICLE
Year : 2021  |  Volume : 6  |  Issue : 4  |  Page : 210-217

Management of hypertension in patients with COVID-19: Implication of angiotensin-converting enzyme 2


1 Department of Medicine-Endocrinology; Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, MO 65212, USA
2 Department of Medicine-Endocrinology; Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine; Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO 65212, USA, USAz

Correspondence Address:
Guang-Hong Jia
Department of Medicine-Endocrinology, University of Missouri School of Medicine, D109 Diabetes Center HSC, One Hospital Drive, Columbia, MO 65212
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2470-7511.334397

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The global coronavirus disease-19 (COVID-19) pandemic, caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), has created an unprecedented, global public health crisis. Epidemiological studies showed that hypertension is a frequent comorbidity, as well as an independent prognostic risk factor in patients with COVID-19. Angiotensin-converting enzyme-2 (ACE-2) is a receptor for SARS-CoV-2, and thus essential for viral entry into human cells. This review summarizes the recent findings of epidemiology of hypertension in COVID-19 patients and highlights the critical role of ACE2. We also review the impact of endothelial dysfunction, inflammation, and arterial stiffness in promoting hypertension and cardiovascular disease in COVID-19 patients. This review also discusses therapeutic strategies for managing hypertension in patients with COVID-19, with particular emphasis on ACE inhibitors, angiotensin receptor blockers, and calcium channel blockers.


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